The answer is simple: General Improvements whenever possible. You may feel overwhelmed by the options of where to spend cells when you first reach the blueprint vendor.

WHAT TO UNLOCK FIRST Motion Twin via Polygon Dying will make you lose all of them, but at the end of each level, you can clean out your bank, spending to unlock a variety of things to help you in future journeys. Cells are those white things that pop out of enemies occasionally. For more about runes and how to unlock them, check out our Dead Cells runes guide.Īnother important aspect of progression: improvements and blueprints which you can unlock by spending “cells” at the end of each level.

Even though you will start from the first level every time you die in Dead Cells, there’s quite a bit that carries forward from each playthrough, making future playthroughs much, much easier.įirst and foremost there are runes which unlock special, Metroidvania-esque abilities, letting you explore new areas.